Seacoast Region Vacations from $439

Book a Hotel + Flight or Car together to unlock savings

Photo by Ana Lei
  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Seacoast Region Vacation

Book a vacation package to Seacoast Region and make planning your adventure easy. With the finer details taken care of before you leave, you can focus on enjoying every second in this wonderful destination. With so many things to explore on a trip to Seacoast Region, it can be hard to know where to start. Kick off your journey in Portsmouth at Water Country and Kittery Premium Outlets — two popular attractions here. Another city worthy of a spot on your itinerary is Rochester. Be sure not to miss The Children's Museum of New Hampshire and Rochester Opera House. If you're ready to stop dreaming and start traveling, Expedia will help turn your Seacoast Region vacation into a reality.

The Latest Seacoast Region vacation packages

Price found within the past 48 hours. Click for updated prices.
Boston Lodge and Suites
The Whitney Hotel
The Inn at Hastings Park, Relais & Chateaux - Boston
The Charles Hotel
Boston Harbor Hotel
Don't see what you're looking for?
See all available trips from Columbus to Seacoast Region
View all trips

Where to stay in Seacoast Region

Find the best Seacoast Region areas and neighborhoods for the activities you enjoy most. Learn more about Seacoast Region

Discover the most popular places to visit in Seacoast Region

Seacoast Region Hotel Deals

Hampton Inn & Suites Portsmouth Downtown

Hampton Inn & Suites Portsmouth Downtown

3 out of 5
23 Portwalk Pl Portsmouth NH
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $128 total per night from Jan 9 to Jan 10
$128 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
9.4/10 Exceptional! (1,097 reviews)
The room was lovely, clean, spacious, well lit with several windows and stocked with paper suplies. The matress was exceptionally comfortable. From the parking valet, to front dask staff to the breakfast staff were all friendly and helpful. The gift wrapping materials a nice touch

Reviewed on Dec 1, 2025

Hampton Inn & Suites Portsmouth Downtown
Fairfield Inn by Marriott Portsmouth-Seacoast

Fairfield Inn by Marriott Portsmouth-Seacoast

2.5 out of 5
650 Borthwick Ave Portsmouth NH
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $110 total per night from Dec 14 to Dec 15
$110 total
Dec 14 - Dec 15
Total with taxes and fees
8.6/10 Excellent! (1,008 reviews)
Great front desk, clean, safe, everything in good condition

Reviewed on Nov 30, 2025

Fairfield Inn by Marriott Portsmouth-Seacoast
Hilton Garden Inn Portsmouth Downtown

Hilton Garden Inn Portsmouth Downtown

3 out of 5
100 High St Portsmouth NH
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $109 total per night from Jan 4 to Jan 5
$109 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
8.2/10 Very Good! (179 reviews)
.

Reviewed on Dec 8, 2025

Hilton Garden Inn Portsmouth Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Seacoast Region Vacation Packages

Seacoast Region Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Manchester-Boston Regional Airport (MHT)

More vacations you might like

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.